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Genetic Risk of Colon Cancer
Wednesday, March 27, 2013 - 10:30 AM (Eastern Time)

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Charis Eng, MD, PhD

  • Genomic Medical Institute
  • Cleveland Clinic

Matthew Kalady, MD

  • Digestive Disease Institute
  • Cleveland Clinic

As March is Colon Cancer Awareness Month, Cleveland Clinic is committed to educating the public on prevention, diagnosis, and treatment of this disease. Some important risk factors include age, African American race, personal and family history of colon cancer and polyps; ulcerative colitis or Crohn’s disease; smoking and being overweight or obese.

Did you know colon cancer is one of the most common cancers? If detected early, it's also one of the most curable. Cleveland Clinic colorectal surgeon Matthew Kalady, MD, and genomic researcher and cancer genetics clinician Charis Eng, MD, PhD will provide answers to your questions about your family history and the genetic components of colon cancer. Keep in mind that the presence of abnormal genes that are related to a certain disease does not mean that a person or his or her children will develop the disease. It means that a person has a higher than average risk for the disease. Hereditary cancer syndromes account for approximately 5 to 10 percent of colon cancer cases. However, external factors, such as environment exposures and diet, might play a role in whether a disease develops.

Charis Eng, MD, PhD, Sondra J. and Stephen R. Hardis endowed Chairwoman of the Genomic Medicine Institute and American Cancer Society Professor at Cleveland Clinic, is the founding Director and attending clinical cancer geneticist of the Institute's clinical component, the Center for Personalized Genetic Healthcare. She is also Professor and Vice Chairman of the Department of Genetics and Genome Science at Case Western Reserve University School of Medicine.

Matthew Kalady, MD, is an Assistant Professor of Surgery in the Department of Colorectal Surgery in Cleveland Clinic’s Digestive Disease Institute. He has a clinical and scientific interest in the causes and treatment of colorectal cancer, including hereditary colorectal cancer syndromes. He is Vice-Chair of the Sanford D. Weiss, MD, Center for Hereditary Colorectal Neoplasia, and Head of the Hereditary Nonpolyposis Colorectal Cancer Section of the Jagelmen Registries. Dr. Kalady also holds the Krause-Lieberman Chair in Colorectal Surgery.

To make an appointment with Charis Eng, MD, PhD, or any of the specialists in the Genomic Medicine Institute at Cleveland Clinic, please call 216.636.1768 or 800.998.4785 (toll-free). You can also visit us online at http://my.clevelandclinic.org/genomics-genetics/genetic-genomic-medicine.aspx.

To make an appointment with Matthew Kalady, MD, or any of the specialists in the Digestive Disease Institute at Cleveland Clinic, please call 216.444.7000 or call toll-free at 866.382.0089. You can also visit us online at www.clevelandclinic.org/score.

This Health Chat will open on Tuesday, March 26, 2013 to allow you to submit questions. We will try to answer as many questions as possible during the chat. Please create an account to attend the chat and submit your questions.